Supplementary data: Characteristics, completion and publication of PROSPERO records in regional anesthesia for acute perioperative pain

These are peer-reviewed supplementary materials for the article 'Characteristics, completion and publication of PROSPERO records in regional anesthesia for acute perioperative pain' published in the Journal of Comparative Effectiveness Research.Supplementary table 1: List of comparators in PROSPERO records in regional anesthesia.Supplementary table 2: List of main efficacy outcomes in PROSPERO records in regional anesthesia.Supplementary Table 3: Safety outcomes planned as one of the main outcomes in PROSPERO records in regional anesthesia.Aim: We analyzed characteristics and completion status of Systematic Reviews (SRs) about regional anesthesia for acute perioperative pain relief registered in PROSPERO. Materials & methods: PROSPERO was searched on 5 January 2022. Characteristics of PROSPERO records, completion status and publication information were extracted. PubMed and Google Scholar were searched by 31 May 2022, for additional published SRs. The inconsistency of PROSPERO records’ status was analyzed by comparing the most recent PROSPERO statuswith subsequent publication of completed SR. Time-to-publication was calculated. Results: Almost half of 174 included PROSPERO records (49%) were registered in 2021. A median of 3 (IQR: 2–4.75) authors, and a search of 4 information sources (IQR: 3–5) was planned. At first registration, 51 (29%) records had already started or completed formal screening. PROSPERO records included mostly adults (48%) undergoing trunk blocks (56%), with pain intensity (74%) as a main outcome. 147 (84%) PROSPERO records had a status “ongoing”. Yet, 71 (41%) PROSPERO records were completed SRs, published after a median of 291 days. Inconsistency in status was found in 34% of PROSPERO records. Conclusion: Despite an increase in PROSPERO registrations about regional anesthesia, most were not published, and a third had inaccurate status.

本数据集为发表于《比较疗效研究杂志》的论文《区域麻醉在急性围术期疼痛中的特点、完成情况及发表情况》的同行评审补充材料。补充表1：PROSPERO记录中区域麻醉的比较对照列表；补充表2：PROSPERO记录中区域麻醉的主要疗效结果列表；补充表3：作为主要结果之一计划的安全结果。研究目的：本研究分析了注册于PROSPERO的系统评价（SR）关于区域麻醉急性围术期疼痛缓解的特点和完成情况。研究材料与方法：于2022年1月5日对PROSPERO进行了检索。提取了PROSPERO记录的特点、完成状态和发表信息。截至2022年5月31日，通过PubMed和Google Scholar检索了额外的已发表SR。通过比较最新PROSPERO状态与已完成SR的后续发表，分析了PROSPERO记录状态的不一致性。计算了发表时间。研究结果：在174项纳入的PROSPERO记录中，近一半（49%）于2021年注册。平均作者人数为3人（IQR：2–4.75），计划检索4个信息来源（IQR：3–5）。在首次注册时，51项（29%）记录已开始或完成正式筛选。PROSPERO记录主要包括成年人（48%）接受躯干阻滞（56%），以疼痛强度（74%）为主要结果。147项（84%）PROSPERO记录状态为“进行中”。然而，71项（41%）PROSPERO记录为已完成SR，发表后中位数为291天。在34%的PROSPERO记录中发现了状态的不一致性。研究结论：尽管关于区域麻醉的PROSPERO注册有所增加，但大多数研究并未发表，其中三分之一的研究状态存在不准确的情况。