Plasma lipoprotein assembly

Because of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport dietary lipids to other tissues in the body. Very low density lipoproteins (VLDL) form in the liver and transport triacylglycerol synthesized there to other tissues of the body. High density lipoprotein (HDL) particles are formed primarily by the liver and shuttle several kinds of lipids between tissues and other lipoproteins (Vance & Vance 1990). The assembly of these three classses of lipoproteins is annotated here.

鉴于其疏水性，脂质主要以脂蛋白复合物的形式存在于人体细胞外间隙。乳糜微粒在小肠中形成，负责将膳食脂质输送到身体其他组织。极低密度脂蛋白（VLDL）在肝脏中形成，并将合成于此处的三酰甘油输送到身体其他组织。高密度脂蛋白（HDL）颗粒主要由肝脏形成，并在组织之间以及其他脂蛋白（Vance & Vance 1990）之间穿梭转移多种脂质。此处对这三类脂蛋白的组装过程进行了注释。