Average results for 40 experimental contact maps from even chromosomes of IMR90.

The maximum entropy optimization uses a convergence criterion of either or . SCC is the stratum-adjusted correlation coefficient [32]. HiC-Spector is the HiC-Spector metric from [33]. Corr PC1() is the Pearson correlation between the first principal component of the genomic-distance normalized contact maps, . RMSE() is the root-mean-squared error between the genomic-distance normalized contact maps. Simulation Time is each method’s total simulation time in minutes. See text for details. All values are mean ± standard error.