Disease onset for mutant (G59S) human dynactin p150^Glued mice.

Disease onset in days ± the standard deviation of male and female transgenic mutant (G59S) human dynactin p150Glued mice in different genetic backgrounds. There was no significant difference in disease onset (p>0.05) between male and female mice in any background. In the three methods for determining disease onset (splay, tremor and ladder down), mice in the B6 (●) background demonstrated significantly (p<0.0005) delayed onset as compared to mice expressing SJL derived genes (SJL, B6/SJL and B17S). In addition, for tremor onset, mice in the B6/SJL (■) background demonstrated significantly (p<0.001) delayed onset as compared to mice in the SJL background. There were no significant difference in disease onset between mice in the SJL background and interval specific congenic mice (B17S). These mice have a pure B6 background except for an SJL derived (chromosome 17 from 16 to 53cM MB) segment.
Disease onset for mutant (G59S) human dynactin p150Glued mice.