Supplementary Material for: Meta-Analysis of <b><i>MMP9</i></b> –1562C/T and the Risk of Coronary Heart Disease

<b><i>Introduction:</i></b> Previous case-control studies have suggested that the –1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene <i>(MMP9) </i>are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis. <b><i>Methods:</i></b> Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed. <b><i>Results:</i></b> The meta-analysis of the –1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The –1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08–1.45, p = 0.004). There was heterogeneity among the 12 studies (I² = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16). <b><i>Conclusions:</i></b> The synthesis of available evidence supports the fact that the <i>MMP9</i> –1562C/T polymorphism is a risk factor for CHD.

**引言：** 既往病例对照研究均提示，基质金属蛋白酶9基因（matrix metalloproteinase 9 gene，MMP9）的–1562C/T与R279Q多态性与冠心病（coronary heart disease，CHD）存在关联，但另有部分研究未能验证上述相关性。本研究旨在通过Meta分析（meta-analysis）评估二者的相关性。**方法：** 检索PubMed、ScienceDirect等数据库以获取基因关联研究相关文献，随后提取研究数据；计算合并比值比（odds ratio，OR）与95%置信区间（confidence interval，CI），并开展亚组分析与敏感性分析。**结果：** 针对–1562C/T多态性的Meta分析共纳入12项研究，涉及8336例病例与3984例对照。结果显示，–1562T等位基因与冠心病存在显著关联（OR=1.25，95%CI=1.08~1.45，p=0.004）。12项研究间存在异质性（I²=61%，p=0.003）；整体研究结果较为稳定，剔除任意单项研究后核心结论未发生显著改变。针对R279Q多态性的Meta分析共纳入6项研究，涉及6983例病例与3282例对照，结果显示R279Q多态性与冠心病无显著关联（p=0.16）。**结论：** 现有证据综合分析表明，MMP9基因–1562C/T多态性是冠心病的危险因素。

搜集汇总

背景与挑战

背景概述

该数据集是2013年发布的关于MMP9基因–1562C/T多态性与冠状动脉心脏病风险关联的荟萃分析补充材料，包含12项研究（总计8,336例病例和3,984例对照）的数据，分析显示–1562T等位基因显著增加CHD风险（OR 1.25, 95% CI 1.08–1.45），而R279Q多态性则无显著关联，旨在综合现有证据评估遗传因素对疾病的影响。数据集以CC BY 4.0许可证共享，便于学术使用和引用。