Impaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- knockout; 3. Deep sequencing of endogenous mRNA from murine embryoinic fibroblast (MEF) insr+/- -lox and insr+/- knockoutJena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
提供机构：
Leibniz Institute for Age Research - Fritz Lipmann Institute
创建时间：
2022-02-20
