ChIP-seq analysis of the Sordaria macrospora wild type and the developmental mutant delta-asf1

Genome-wide distribtuion of histone H3K56ac (histone H3 acetylated at lysine 56) was analyzed in the wild type and the sterile mutant asf1. The asf1 gene encodes a conserved histone chaperone, and preliminary experimentes indicated changes in histone modifications in the mutant that were analyzed on a genome-wide basis in these experiments. The analysis was carried out with mycelia from the wild type and the delta-asf1 mutant. Two biologically independent replicates were obtained for each strain.