Genes whose expression was significantly (P≤0.05) influenced by estradiol (E2) treatment at all doses tested.

For each gene the log2 value of the fold change is given, and thus up-regulated and down-regulated genes are reflected in positive and negative numbers respectively. Genes are sorted first according to the cluster groups identified for the low-dose treatments (see Methods), and then by whether the trend at the high dose (100 nM) is consistent with the results seen at lower doses. Y = monotonic trend; gene expression at 100 nM E2 continues the trend at lower doses or has reached a plateau at that point. N = trend is clearly not monotonic; gene expression at 100 nM E2 is in the reverse direction of the trend at lower doses. I = suggestion of non-monotonic trend; gene expression at 100 nM shows slight reversal of trend at lower doses. *Value is average value for all probes for this gene (n = 5).