Inhibiting CXCR4 Reduces Immunosuppressive Effects of Myeloid cells in Breast Cancer Immunotherapy

The goal of this experiment is to understand effects of combining CXCR4 inhibitor balixafortide with an anti-PD-1 immune checkpoint inhibitor on response to therapy in a mouse model of triple-negative breast cancer. Overall design: There are triplcate samples of isolated cancer and tumor-infilatrating immune cells from mouse breast cancer E0771 tumors.