Association of DENND1A gene polymorphisms with polycystic ovary syndrome in Saudi Arabian women

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and a leading cause of infertility among women of reproductive age. Despite its increasing prevalence, the underlying molecular etiology remains poorly understood. Increasing evidence implicates genetic variants in DENND1A, a gene involved in endosomal trafficking and androgen biosynthesis regulation, in PCOS susceptibility. This study investigated the association of three intronic single-nucleotide polymorphisms (SNPs) (rs10818854, rs2479106, and rs10986105) within DENND1A with PCOS in Saudi Arabian women.