Data from: Inferring the age of a fixed beneficial allele
收藏DataONE2015-11-16 更新2024-06-27 收录
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Estimating the age and strength of beneficial selected alleles is central to understanding how adaptation proceeds in response to changing environmental conditions. Several haplotype-based estimators exist for inferring the age of actively segregating beneficial mutations. Here we develop an approximate Bayesian approach that rather estimates these parameters for fixed beneficial mutations. We integrate a range of existing diversity, site frequency spectrum, haplotype and linkage disequilibrium statistics. We show that for strong selective sweeps, the method can estimate allele age and selection strength even in non-equilibrium demographic scenarios. Finally we apply our method to estimating the age and selection strength of a previously identified mutation underpinning cryptic color adaptation in a wild deer mouse population, and compare our findings with previously published estimates.
创建时间:
2015-11-16



