The top SNPs in each of the 9 sub-blocks in the <i>UGT1A</i> gene region (see Figure 2).

The four SNPs that are associated most significantly with serum cf-DNA levels are in sub-block 8. †For each SNP, the ancestral allele was modelled, and the β coefficient represents the change in cf-DNA level (µg/ml) with one additional copy of the ancestral allele. *Adjusted for age, sex, BMI and genetic East-West stratification in the Finnish population. Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pairs; MAF, minor allele frequency; S.E., standard error.