DUSP22-FASN
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资源简介：
Induction of fatty acid synthase (FASN) occurs in obesity and obesity-related diseases. Dual-specificity phosphatase 22 (DUSP22) is a negative regulator of cancer progression and inflammatory diseases; however, the <i>in vivo</i> role of DUSP22 in metabolic syndrome remains unclear. We found that Dusp22 KO mice spontaneously developed obesity and displayed high FASN levels in insulin-responsive tissues. Mechanistically, DUSP22 dephosphorylated FASN protein at three residues, resulting in degradation of FASN and subsequent suppression of adipogenesis.
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Chuang, Huai-Chia创建时间：
2024-08-16
