Safety and Biochemical Measurements at Baseline and Changes on Study.

Data are the mean (SD). All measurements were performed under fasting conditions. The significance of differences between treatment groups in the changes from baseline at weeks 2 and 14 was determined by unpaired t-tests, and differences that are statistically significant (PAbbreviations: HOMA-IR: Homeostasis model assessment of insulin resistance (20).To convert to SI units: creatine ��g/mL to ��mol/L multiply by 7.625; creatinine mg/dL to ��mol/L multiply by 88.4; triglycerides mg/dL to mmol/L multiply by 0.01129; cholesterol mg/dL to mmol/L multiply by 0.02586; glucose mg/dL to mmol/L multiply by 0.05551; insulin ��IU/mL to pmol/L multiply by 7.175.