COVID HOME

General Design

Type: Cohort study
Cohort type: Population cohort

Design description:
A prospective longitudinal observational study of COVID-19 outpatients was established in March 2020 at the beginning of the COVID-19 pandemic in the Netherlands. Laboratory confirmed SARS-CoV-2 infected individuals of all ages that did not merit hospitalisation, and their household (HH) members, were enrolled after written informed consent. Enrolled participants were visited at home within 48 hours after initial diagnosis, and then weekly on days 7, 14 and 21 to obtain clinical data, a blood sample for biochemical parameters/cytokines and serological determination; and a nasopharyngeal/throat swab plus urine, stool and sperm or vaginal secretion (if consenting) to test for SARS-CoV-2 by RT-PCR (viral shedding) and for viral culturing. Weekly nasopharyngeal/throat swabs and stool samples, plus a blood sample on days 0 and 21 were also taken from HH members to determine whether and when they became infected. All participants were invited to continue follow-up at 3-, 6-, 12- and 18-months post-infection to assess long-term sequelae and immunological status.

Start/End data collection: 2020 until 2024

Population

Countries: Netherlands (the)
Regions: Drenthe, Friesland, Groningen
Number of participants: 270
Population age groups: All ages
Other inclusion criteria:
"Onset of symptoms <5 days before inclusion, Positive diagnostic RT-PCR for SARS-CoV-2 performed within 48h of inclusion, Index person should supply all required samples in the protocol for the duration of the study, All HH members should join the study, Signing of informed consent form"