Lactacidosis impairs energy homeostasis of primary vascular smooth muscle cells - possible pathomechanisms during septic vasoplegia

RNAsequencing was performed for human primary aortic smooth muscle cells (HAoSMCs) from male donors, after incubation at pH 7.4 (control condition or with Na+-Lactate) or at pH 6.8 (ajusted with HCl or lactic acid). HAoSMCs were incubated at pH 7.4 (control condition or with Na+-Lactate) or at pH 6.8 (ajusted with HCl or lactic acid) for 48 h (N = 5)