Modelling G2019S-LRRK2 sporadic Parkinson’s disease in 3D midbrain organoids
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125234
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资源简介：
Recent advances in generating 3 dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling. In this study, we generate isogenic 3D midbrain organoids with or without a Parkinson’s disease-associated LRRK2 G2019S mutation. LRRK2-G2019S midbrain organoids derived from LRRK2 targeted human iPSCs in vitro have LRRK2-associated sporadic Parkinson's disease phenotypes. Midbrain-like 3D organoids expressing LRRK2-G2019S showed dynamic changes in globle gene expression. Affymetrix GeneChip Human Gene 1.0 ST Array was performed according to the manufacturer's protocol. Changes in the gene expression profile of 2D control, 2D LRRK2-G2019S, 3D midbrain organoids and LRRK2-G2019S 3D oragnoids
创建时间：
2019-03-28
