PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 7).
收藏Protein Data Bank Japan2024-12-25 更新2026-04-25 收录
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PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 7). Descriptor: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, 2-[[(1~{R})-1-(7-methyl-4-oxidanylidene-2-piperidin-1-yl-3~{H}-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... Authors: Gunn, R.J, Lawson, J.D. Deposit date: 2023-12-06 Release date: 2024-03-20 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3K alpha Mutant Protein. J.Med.Chem., 67, 2024
创建时间：
2023-12-06
