Accelerated Intermittent Theta Burst Stimulation (iTBS) Decreased Cigarette Cue Attentional Bias (AB) in People With Comorbid Opioid Use Disorder (OUD) and Tobacco Use Disorder (TUD). A Pilot Study

This dataset encompasses examining the effects of the impact of accelerated intermittent theta burst stimulation (iTBS) versus sham iTBS (comprising four sessions in a day, 1800 pulses/session, delivered in an accelerated manner, at intervals of 50 minutes) on tobacco/opioid cravings and cue attentional bias (AB) for opioids/cigarettes in people with tobacco use disorder (TUD) and opioid use disorder (OUD). This is a pilot study, participants with both TUD and OUD were randomized to receive iTBS (n=8) or sham iTBS (n=7).

Study Procedures. After completing a phone screen to determine eligibility, participants were scheduled for Day 1 procedures, which consisted of informed consent, collection of demographic details, measuring carbon monoxide (CO) using a Smokerlyzer Breath CO Monitor (Bedfont Scientific Ltd., Rochester, England), measuring blood alcohol level (BAL) using a Breathalyzer, administering Fagerstrom Test for Nicotine Dependence (FTND), an attentional bias screen (AB Screen) and structural MRI of the brain. All eligible study participants were randomized and scheduled to receive iTBS or sham iTBS a week from Day 1 (Day 2). On day 2, participants received four sessions of iTBS or sham iTBS at intervals of 50 minutes between sessions. The following assessments were administered in the indicated order at 3-time points (baseline, after the 1st session of iTBS/sham iTBS, and after the 4th session of iTBS/sham iTBS) - 1) cigarette cue AB measured with eye tracking (gaze fixation time), 2) opioid cue AB measured with eye tracking, 3) cigarette craving assessed using the short form version of tobacco craving questionnaire (TCQ-SF), and 4) opioid craving assessed using the opioid craving scale (OCS).

Dataset Description. The dataset comprises 2 sheets, one for changes in TUD metrics and the other for changes in OUD metrics. Column 1 in both sheets lists participant ID, column 2 lists treatment arm assignment (iTBS versus sham iTBS), column 3 indicates time points (baseline, after 1 session and after 4 sessions), column 4 indicates type of cues (people smoking cigarettes or using opioids/ cigarette or opioid paraphernalia), column 5 indicates Fagerstrom (FTND) scores, column 6 lists craving scores (TCQ-SF on Sheet 1, OCS scores on Sheet 2) and column 7 lists cue AB in milliseconds. AB is derived by subtracting the gaze fixation on neutral cues from the gaze fixation on cigarette/opioid cues.

本数据集旨在探讨加速间歇性θ波爆发放电（iTBS）与安慰剂iTBS（每日四次，每次1800脉冲，以加速方式，每隔50分钟进行）对烟草/阿片类药物渴求以及阿片类药物/香烟的线索注意力偏差（AB）在烟草使用障碍（TUD）和阿片类药物使用障碍（OUD）患者中的影响。这是一项试点研究，患有TUD和OUD的参与者被随机分配接受iTBS（n=8）或安慰剂iTBS（n=7）。

研究流程。在完成电话筛查以确定资格后，参与者被安排在第一天进行程序，包括知情同意、收集人口统计学详细信息、使用Smokerlyzer呼吸CO监测器（Bedfont Scientific Ltd.，英格兰罗切斯特）测量一氧化碳（CO）水平、使用酒精呼吸测试仪测量血液酒精水平（BAL）、执行Fagerstrom尼古丁依赖测试（FTND）、进行注意力偏差筛查（AB筛查）和脑部结构MRI检查。所有合格的研究参与者均被随机分配并在第一天之后的一周（第二天）接受iTBS或安慰剂iTBS。在第二天，参与者接受了四次iTBS或安慰剂iTBS，每次之间间隔50分钟。在三个时点（基线、iTBS/安慰剂iTBS第一次会话后以及iTBS/安慰剂iTBS第四次会话后）按照指示顺序进行了以下评估：1）使用眼动追踪测量香烟线索AB，2）使用眼动追踪测量阿片类药物线索AB，3）使用烟草渴求问卷简表（TCQ-SF）评估香烟渴求，4）使用阿片类药物渴求量表（OCS）评估阿片类药物渴求。

数据集描述。该数据集包含两页，一页用于记录TUD指标的变化，另一页用于记录OUD指标的变化。两页的第一列列出参与者ID，第二列列出治疗臂分配（iTBS与安慰剂iTBS），第三列表示时间点（基线、1次会话后和4次会话后），第四列表示线索类型（吸烟者吸烟或使用阿片类药物/香烟或阿片类药物附属品），第五列表示Fagerstrom（FTND）得分，第六列列出渴求得分（第一页上的TCQ-SF得分，第二页上的OCS得分）和第七列列出线索AB的毫秒数。AB是通过从中性线索的注视固定时间中减去香烟/阿片类药物线索的注视固定时间来计算得出的。