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Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints

ChEBI2010-07-29 更新2026-07-21 收录

免疫疗法机制

调节性T细胞功能

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-22527 数据链接链接失效反馈

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Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints

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创建时间：

2010-07-29

调节性T细胞功能

转录调控机制

We investigated the role of Ikaros in regulatory Tcell identity and function during stimulation using RNA-seq, ATAC-seq, and H3K27ac/Foxp3/Ikzf1 ChIP-seq Overall design: We performed ATAC-seq, RNA-seq

NIAID Data Ecosystem80

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Mus musculus

调节性T细胞功能

免疫转录调控

Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression

NIAID Data Ecosystem30

Global Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells. Homo sapiens

表观遗传调控

调节性T细胞功能

Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differ

NIAID Data Ecosystem20

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

调节性T细胞功能

自身免疫疾病机制

BackgroundCD4+CD25+FOXP3+ Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in

NIAID Data Ecosystem40

Immunomodulation of Antigen Presenting Cells Promotes Natural Regulatory T Cells That Prevent Autoimmune Diabetes in NOD Mice

自身免疫疾病免疫治疗

调节性T细胞功能

Progression towards type 1 diabetes (T1D) in susceptible patients is linked to a progressive decline in the capacity of regulatory T cells (Treg) to maintain tolerance. As such, therapies aimed at red

Figshare2016-01-18 更新30

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints

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