Structural snapshots of R-loop formation by a type I-C CRISPR-Cascade
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2024-04-30
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The G-rich repeats in FMR1 and C9orf72 loci are hotspots for R-loop retention and for local unpairing of DNA. The G-rich repeats in FMR1 and C9orf72 loci are hotspots for R-loop retention and for local unpairing of DNA
We finely mapped single strand DNA displacements in FMR1 and C9orf72 and RPLA13A, a non-repetitive control locus. Overall design: Single strand DNA displacements were mapped by locus-specific DNA deep
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type I-C Cascade bound to ssDNA target
type I-C Cascade bound to ssDNA target Descriptor: CRISPR-associated protein, CT1133 family, TM1801 family, ... Authors: O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W.
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WT CRISPR-Cas12a with a 10bp R-loop
WT CRISPR-Cas12a with a 10bp R-loop Descriptor: CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*CP*AP*CP*TP*TP*AP*TP*CP*AP*CP*TP*AP*AP*AP*AP*GP*AP*TP*CP*GP*GP*AP*AP*G)-3'), DNA (5'-D(P*CP*TP*TP*CP*
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High-Throughput Single-Molecule R-loop Footprinting Reveals Principles of R-loop Formation. High-Throughput Single-Molecule R-loop Footprinting Reveals Principles of R-loop Formation
We have successfully characterized R-loop structures using non-denaturing bisulfite treatment coupled with single-molecule sequencing to reveal that R-loops form defined overlapping molecular clusters
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Genome-wide relationship between R-loop formation and antisense transcription in Escherichia coli. Genome-wide relationship between R-loop formation and antisense transcription in Escherichia coli
Transcription termination by Rho is essential for viability in various bacteria, including some major pathogens. Since Rho acts by targeting nascent RNAs that are not simultaneously translated, it als
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