Effects of viral SNPs in relation to enhanced viral load and HCC on coding function by HBV genomic regions.

aa, amino acid; CAD, cytosolic anchorage determinant; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; Hsc70, heat shock protein 70-binding site; Nt, nucleotide; ORF, open reading frame; pHSA, polymerized human serum albumin-binding site; RT, reverse transcriptase; S, surface; SNPs, single nucleotide polymorphisms.aBased on deduced aa site of the HBV large envelope protein.bSpecific types of SNPs (deletions or aa substitutions) exhibiting significantly altered frequency (determined by Fisher’s exact test) in HCC cases, as compared with non-HCC controls, are shown in bold.cAll shown as consensus aa type.