Tamoxifen treatment as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)

In this study, we performed RNA sequencing on tibialis anterior muscle of male mice of 7 weeks of age. WT and Mtm1 deficient (Mtm1-/y) mice as well as tamoxifen-treated WT and tamoxifen-treated Mtm1-/y mice were sequenced. Overall design: The study is composed of 4 groups of mice: WT, Mtm1-/y, WT Tamox and Mtm1-/y Tamox. Each group was composed of triplicates or quadruplicates. The comparison of transcriptome profiles across the different genotypes was assessed in this study.