Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: Etiology and sex-dependent differences

This dataset contains the source data supporting the article entitled Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: Etiology and sex-dependent differences. The dataset supports key findings in recent two-hit translational animal models of heart failure with preserved ejection fraction (HFpEF), including the hypertensive, nitrosative-stressed mice fed with high-fat diet and L-NAME (HFD+L-NAME) and the obese-diabetic leptin receptor-deficient db/db mice with excess aldosterone (db/db+Aldo), which may phenocopy select subgroups of HFpEF. Morphometry, echocardiography, electrophysiology (action potentials and ionic currents), fluorescent Ca imaging, and RNA sequencing data are included in separate Excel sheets with individual cell data and group statistics. The dataset is structured to follow the sequence of data presented in the Figures in the article and to ease the navigation between the uploaded data files.