2‑Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones

We
introduce a new strategy for synthesis of chiral amines: couplings
of α-aminoalkyl nucleophiles generated by enantioselective migratory
insertion of 2-azadienes to a Cu–H. In this report, we demonstrate
its application in catalytic reductive coupling of 2-azadienes and
ketones to furnish 1,2-amino tertiary alcohols with vicinal stereogenic
centers.