Comparative analysis of REST and CoREST promoter occupancy and corresponding gene expression profiles during neuronal developmental transitions.

We evaluated specification of neuronal subtypes from their most proximate progenitors, including the developmental transition of specific NSC species into their corresponding mature neuronal subtypes (CHOLNs and MSNs), of radial glia (RG) into GLUTNs, and of bipotent neuronal-OL progenitors (N/OPs) into GABANs. The absence or presence of REST and CoREST promoter occupancy for target genes within each cell type are indicated by no and yes, respectively. Each pair of numbers represents genes up regulated and down regulated (+/−), respectively, during the transition from the proximal progenitor (column A) to its immediate progeny (column B).