Comparison of the transcriptome of KP4 controls or resistant to Folfirinox after 96h of treatment with Vehicule or Folfirinox

FOLFIRINOX induces senescence in pancreatic tumor cells. However, some cells can spontaneously escape this senescence. We wanted to characterize the escape mechanisms from FOLFIRINOX-induced senescence of pancreatic tumor cells. Our in vitro adaptation model to FOLFIRINOX shows that cells that have already escaped 5 treatment cycles become less sensitive to FOLFIRINOX. Overall design: RNA sequencing was performed to compare KP4 cells that were either untreated (DMSO) or treated with FOLFIRINOX for 4 days. Additionally, KP4 cells were analyzed after undergoing 5 cycles of the same treatment (DMSO or FOLFIRINOX).