Transcript changes in primary Leydig cells treated with Sertoli cell released exosomes. Transcript changes in primary Leydig cells treated with Sertoli cell released exosomes

In this study, we aim to figure out if Sertoli cells released exosomes can regulate the survival and steroidogenesis of Leydig cells. We found Sertoli cells released exosomes can cross the blood-testis barrier, deliver their contents into the Leydig cells, and promote the survival of Leydig cells through CCL20. Overall design: Two groups of RNA samples isolated from Leydig cells were included, each group has three replicates (n=3). Group A was reference, the cells were not treated with exoxomes. The cells in Group B were treated with exoxomes.