Engulfed CpG DNA binds to endosomal C-ter TLR9

Synthetic oligodeoxynucleotides (ODN) expressing non-methylated CpG motifs patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern by TLR9, and triggers a rapid innate immune response.

合成性寡脱氧核苷酸（ODN），其表达的未甲基化的CpG基序模式模仿细菌DNA中的相应基序，具有特有的免疫调节作用。CpG DNA被Toll样受体9（TLR9）识别为病原体相关分子模式，并引发快速的先天免疫反应。