Single-cell profiling reveals tumor microenvironmental features and the role of activated B cells in cancers with liver metastasis

Liver is the common site for metastases of colorectal cancer (CRC), breast cancer, and lung cancer. In particular, more than 40% of patients with late-stage CRC develop liver metastasis (LM). However, key immune cells involved in liver metastasis are unknown. Here, we used single-cell sequencing to identify key immune cells and study their function in tumor immune microenvironment (TIME) of CRC-LM