Pre-registered blind structural predictions for 11 proteins — DON Research engine v1

Blind structural predictions for 11 proteins (TP53, SOD1, lysozyme, HBB, KRAS, CYCS, ubiquitin, calmodulin, APOE, alpha-synuclein, UQCRB) generated by the DON Research engine on 2026-03-15 from amino acid sequences alone, with no training data and no structural information provided as input. Predictions classify each residue as core / surface / middle based on the engine's recursive collapse dynamics. Verification against published structural biology literature (Cho et al. Science 1994; Tainer et al. Nature 1982; Blake et al. Nature 1965; Perutz et al. Nature 1960; Pai et al. EMBO J 1990; Bushnell et al. JMB 1990; Vijay-Kumar et al. JMB 1987; Babu et al. Nature 1985; Wilson et al. Science 1991; Ulmer et al. JBC 2005; Iwata et al. Science 1998) was performed on 2026-03-16. Overall accuracy: 110 of 114 scored predictions = 96.5%, with full per-position breakdown and miss analysis included in the verification file. Files:- substrate_dynamic_predictions_2026-03-15.txt — primary prediction set (normalized Psi)- full_output_2026-03-15.txt — secondary prediction set (raw spectral values)- verification_2026-03-15.txt — position-by-position scoring against literature with citations- verification_console_2026-03-15.txt — console output of the verification run This deposit externalizes the prediction artifacts produced on 2026-03-15 to provide a third-party-verifiable timestamp via Zenodo's CERN-backed archival infrastructure. Files are byte-identical to their original generation; SHA-256 / MD5 hashes are visible in the file metadata above. Methodology, scope, and limitations are discussed in the analysis notes section of the verification file. Two prediction misses (TP53 C238/C242) and the SOD1 A4 result are explicitly disclosed as 1D-topology limitations or sequence-numbering artifacts rather than dropped from the score.