Truncated BRPF1 cooperates with Smoothened to induce adult Shh medulloblastoma

We performed ATAC-seq analysis, in order to understand the role of SmoM2 and truncated BRPF1 on the epigenetic landscape during medulloblastoma disruption Overall design: We performed ATAC-seq analysis on frozen cerebella from Gabra6-cre;LSL-SmoM2 and control Gabra6-cre mice and on hSynI-creER+LSL-tdTomato, hSynI-creER+LSL-BRPF1 TR, hSynI-creER+LSL-SmoM2 and hSynI-creER+LSL-SmoM2+LSL-BRPF1 TR nucleofected AF22 neuroephitilial-like stem cells