Selected gene signatures significantly enriched or depleted in the ABC meta-profile.

Gene signature enrichments in the meta-profiles were assessed with a hypergeometric test. Shown are selected signatures discussed in the text, including those related to the reciprocal class, a comprehensive list is provided in Table S8. Gene Signature: name of signature, Overlapping: how many of the ABC meta-profile genes overlap with signature, GeneSigSize: number of genes in gene signature (after classifier genes are removed), randAvg/randSD: average/standard-deviation overlap from distribution containing 1 million random samplings, %Overlap: percentage of gene signature that overlaps with meta-profile, Zscore: standard score of observed normalised against random distribution, FDR: Benjamini-Hochberg false discovery rate, Source: gene signature origin. Shown is a selection of gene signatures (see Table S8 for complete list). ** FDR * FDR