Novel risk variants affecting enhancers of TH1 and TREG cells in type 1 diabetes [RNA-seq]

We generated expression profiles of TH1 and TREG cells from T1D and healthy subjects by RNA-Seq. By integrating RNA-Seq dta with other data sets, we predicted and validated serveral T1D risk SNPs. Overall design: Effector memory TH1 and effector memory TREG cells were isolated from 6 T1D patients and mached 5 helathy controls. Gene expression profilings were generated using RNA-Seq. By integrating RNA-Seq data, ChIP-Seq and other data sets, we predicted and validated several risk SNPs for T1D.