Synthesis of 3-Aminolactams as X-Gly Constrained Pseudodipeptides and Conformational Study of a Trp-Gly Surrogate
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https://figshare.com/articles/dataset/Synthesis_of_3_Aminolactams_as_X_Gly_Constrained_Pseudodipeptides_and_Conformational_Study_of_a_Trp_Gly_Surrogate/3375856
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资源简介：
3-Amino-δ-valerolactams trans-11a−c were synthesized through conjugate addition and Curtius
rearrangement and converted into Fmoc-{Trp-Gly}, Fmoc-{Ile-Gly}, and Fmoc-{Phe-Gly} pseudodipeptides. Conformational analyses of tripeptide analogues Ac-{Trp-Gly}-Leu-NH2 17a and 17b
by NMR experiments and molecular modeling calculations showed that diastereomer 17a adopted
a γ-turn/distorted type II β-turn structure, whereas diastereomer 17b adopted mainly a γ-turn
structure.
创建时间：
2016-05-12
