Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response.

One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours, which leads to tumour recurrence and, ultimately, patient death To investigated this we analyze plasticity of chemotherapy-resistant cells Gene expression profiling analysis of RNA-seq data for HeLa control cells versus Hela cells treated 24 hours with TRAIL (30 ng/ml), Camptothecin (10 µM) or Doxorrubicin (2 µM).