SNP.xlsx

A total of 507 unrelated patients with IS from the northeastern Chinese Han population were consecutively recruited from the same center and included in this study. All recruited patients were diagnosed by an experienced neurologist according to their clinical features and by auxiliary diagnosis, including computed tomography (CT) and/or magnetic resonance imaging (MRI) and routine laboratory tests. Based on these complications, the case group was divided into an IS with or without hypertension subgroup and with or without diabetes subgroup. Based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification the IS patients were further categorized into atherothrombosis subtype, lacunar infarction subtype and both atherothrombosis and lacunar infarction subtype(Adams et al., 1993). The control group consisted of 503 unrelated gender-matched and geography-matched healthy individuals from the Health Medical Center, they were without stroke, hypertension, diabetes, heart disease, and other central nervous system disorders.