Transcriptome profiling of colon biopsies from pre-clinical models of colitis. Transcriptome profiling of colon biopsies from pre-clinical models of colitis

We carried out genome-wide expression profiling of colon biopsies from innate, adaptive and chemically-induced models of colitis and corresponding control mice to investigate their similarities and differences at the molecular level. Overall design: Comparative analysis of transcriptomic profiles from colonic biopsies of mice with colitis induced by DSS, DNBS, T-cell transfer, anti-CD40 antibodies, IL-10 deficiency or T-bet-/- × RAG2-/- deficiency.