ULK1 is dephosphorylated

Under starvation conditions ULK1 undergoes dephosphorylation, particularly at serine-639 and serine-758 (Shang et al. 2011). The S757 unphosphorylated ULK1 is able to associate with, and be activated by, AMPK (Egan et al. 2011). The protein phosphatase(s) involved in ULK1 dephosphorylation are currently unknown (Wong et al. 2013).

在饥饿状态下，ULK1蛋白发生去磷酸化，特别是在丝氨酸-639和丝氨酸-758位（Shang et al. 2011）。去磷酸化的S757 ULK1蛋白能够与AMPK结合，并由此被激活（Egan et al. 2011）。参与ULK1去磷酸化的蛋白磷酸酶目前尚不明确（Wong et al. 2013）。