Crystal Structure of SETDB1 Tudor domain in complex with UNC100013

Crystal Structure of SETDB1 Tudor domain in complex with UNC100013 Descriptor: (2E)-4-(dimethylamino)-N-(4-{[6-(dimethylamino)hexyl]amino}-2-{[5-(dimethylamino)pentyl]amino}quinazolin-6-yl)but-2-enamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ... Authors: Silva, M, Dong, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2024-07-26 Release date: 2024-10-02 Last modified: 2025-10-22 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nat Commun, 16, 2025