TASL recruits IRF5

Following activation of endosomal Toll like receptors (TLR7, TLR8, and TLR9), the SLC15A4:TASL complex mediates the recruitment of interferon regulatory factor 5 (IRF5) to its pLxIS motif (Heinz LX. et al., 2020). The formation of SLC15A4:TASL complex facilities IRF5 phosphorylation and subsequent IRF5 homodimerization downstream of endosomal TLR7-9 (Heinz LX. et al., 2020; Zhang H et al., 2023; Chen X et al., 2023; Boeszoermeny A et al., 2023). Once activated, IRF5 translocates to the nucleus to induce the transcription of genes encoding type I interferons (IFNs) and pro-inflammatory cytokines.

在端粒Toll样受体（TLR7、TLR8和TLR9）被激活之后，SLC15A4:TASL复合体介导干扰素调节因子5（IRF5）与其pLxIS基序的结合（Heinz LX. 等，2020）。SLC15A4:TASL复合体的形成促进了IRF5的磷酸化，并随后在端粒TLR7-9下游引发IRF5的同源二聚化（Heinz LX. 等，2020；张H. 等，2023；陈X. 等，2023；Boeszoermeny A. 等，2023）。一旦被激活，IRF5将转移至细胞核，从而诱导编码I型干扰素（IFNs）和促炎细胞因子的基因的转录。