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Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils. Longo et al.

NIAID Data Ecosystem2026-05-02 收录

染色质三维折叠

II型拓扑异构酶

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https://data.mendeley.com/datasets/f893zhsz3c 数据链接链接失效反馈

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Dataset for "Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils"

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创建时间：

2024-10-07

果蝇剂量补偿

II型拓扑异构酶

Investigate Topo II levels in dosage compensated and non-dosage compensated genes Dosage compensation refers to the equalization of most X-linked gene products between males and females. In Drosophila

NIAID Data Ecosystem80

Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia

缺氧激活前药研发

II型拓扑异构酶

In spite of the tremendous efforts dedicated to developing hypoxia-activated prodrugs, no agents yet have been approved for clinical therapy. In the present study, the hypoxic selective anti-cancer ac

NIAID Data Ecosystem30

AMP-PNP-stabilized ATPase domain of topoisomerase IV from Streptococcus pneumoniae, complex type II

DNA复合物

II型拓扑异构酶

AMP-PNP-stabilized ATPase domain of topoisomerase IV from Streptococcus pneumoniae, complex type II Descriptor: DNA (5'-D(*GP*CP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*GP*C)-3'), DNA topoisomerase 4 subunit B,

Protein Data Bank Japan2024-01-10 更新20

Topoisomerase II-induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity [Nascent RNA]

II型拓扑异构酶

基因组不稳定性

Topoisomerase II (TOP2) relieves torsional stress during transcription, DNA replication and chromosome segregation, by forming transient cleavage complex intermediates (TOP2ccs) that contain TOP2-link

NIAID Data Ecosystem50

Distinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)

抗癌药物机制

II型拓扑异构酶

One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines

NIAID Data Ecosystem30

Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils. Longo et al.

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