Isothiourea-Mediated One-Pot Synthesis of Trifluoromethyl Substituted 2‑Pyrones
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https://figshare.com/articles/dataset/Isothiourea_Mediated_One_Pot_Synthesis_of_Trifluoromethyl_Substituted_2_Pyrones/2325415
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资源简介：
A one-pot
isothiourea-mediated Michael addition/lactonization/thiol
elimination cascade sequence for the formation of 4,6-disubstituted
and 3,4,6-trisubstituted 2-pyrones from (phenylthio)acetic
acids and α,β-unsaturated trifluoromethyl
ketones is described. The synthesis of a COX-2 inhibitor and the wide-ranging
derivatization of the 2-pyrone moiety to trifluoromethyl substituted
aromatics and heteroaromatics is also disclosed.
创建时间：
2014-02-07
