Supplementary Material for: Darier’s Disease Successfully Treated with Tofacitinib: A Case Report

Darier’s disease (DD) is a rare autosomal dominant genodermatosis characterized by keratotic papules, predominantly affecting seborrheic areas. We report a 42-year-old woman who developed pruritic brown papular lesions on her trunk, particularly under the breasts, groin, and neck. A biopsy confirmed Darier’s disease, and she was treated with adalimumab, which failed to provide clinical improvement. The patient was then started on tofacitinib 10 mg daily, leading to disease stabilization. Due to persistent itching and new lesions, the dose was increased to 15 mg daily, resulting in significant improvement. After a few months, with most lesions resolved, the dose was reduced to 10 mg daily, successfully maintaining disease control. This case highlights the potential role of JAK inhibitors as an effective treatment option for refractory Darier’s disease.