YAP1 fusion proteins drive forebrain ependymoma tumorigenesis via the interaction with TEAD transcription factors

A mouse model has been generated resembling human YAP1 fusion-positive supratentorial ependymoma. We show that the YAP1-MAMLD1 fusion, which is the most recurrent fusion in this distinct type of ependymomas, is able to drive malignant transformation in mice. The resulting brain tumors resemble histo-molecular characteristics of their human counterparts. Ten mouse brain tumors induced by electroporating either a human YAP1-MAMLD1 fusion construct or a human C11orf95-RELA fusion construct into cerebral ventricular zone cells of fetal mice at E13.5 were profiled on the Affymetrix Mouse Genome mm430.2 array.