Research data for the article "Charge of a Transmembrane Peptide Alters Its Interaction with Lipid Membranes" by Thakur et al. Colloids and Surfaces B: Biointerfaces, 2024

Research data for the publication Thakur, G.C.N., Uday, A., Cebecauer, M., Roos, W.H., Cwiklik, L., Hof, M., Jurkiewicz, P., and Melcrová, A. Charge of a Transmembrane Peptide Alters Its Interaction with Lipid Membranes. Colloids and Surfaces B: Biointerfaces, 2024. https://doi.org/10.1016/j.colsurfb.2024.113765

The data set contains experimental and simulation data on the study of transmembrane peptides WALP-KD and WALP-KK4+ and their interaction with model lipid membranes. Experimental and simulation details can be found in the Materials and Methods section of the mentioned article. 

The data set contains:

Files starting with "Figure..." contain source data used for the generation of the figures in the mentioned article.

Atomic Force Microscopy images are in the raw format as collected on JPK Nano Wizard Ultra Speed AFM.

Force-indentation curves from the force measurements by JPK Nano Wizard Ultra Speed AFM in the *.txt format. These curves were used for the analysis of the mechanical properties of the membranes with and without the transmembrane peptides.

Line profiles (cross-sections) over the height of the supported membranes and the surrounding support. Extracted from the height images measured on JPK Nano Wizard Ultra Speed AFM.

Molecular Dynamic simulation data - configuration files, trajectories, density profiles of chosen parts of the membrane alongside the membrane axis. These files are in respective directories for all simulated systems: POPC 100%, POPC/POPS 80/20 mol%, and both with the addition of 3 mol% peptide WALP-KD or WALP-KK4+.