Differentially methylated probes for each cell population in comparison to whole blood.

PBMC-Peripheral blood mononuclear cells. Differentially methylated probes were defined by a linear model using the M-values. M-value is the log2 ratio of the intensities of methylated probe versus unmethylated probe, a measurement of how much more a probe is methylated compared to unmethylated [46]. *To extract the probes with largest difference in methylation, a gamma fit model was applied to M-values in order to define the three calls: “unmethylated”, “marginal” and “methylated”. Significant probes sharing the same call in the two compared populations were removed. **Variation is based on the estimate of the log2-fold-change corresponding to the effect obtained from the linear model, absolute M-values are presented. The percentages are based on the call distribution.