Analysis of human leukocyte antigen (HLA) allotype-specific response in abacavir-exposed keratinocyte

Abacavir, a nucleoside reverse-transcriptase inhibitor used for the treatment of human immunodeficiency virus (HIV) infection, develops hypersensitivity in patients carrying HLA-B*57:01 allele through drug antigen presentation. We found that abacavir exposure induced HLA allotype-specific innate immune response in keratinocyte derived from HLA-B*57:01 transgenic mice. Therefore, the mechanism of the novel response was analyzed comprehensively. Gene expression profile of HLA allotype-specific response of abacavir-exposed keratinocyte derived from HLA-B*57:01 transgenic mice, compared to that of keratinocyte derived from HLA-B*57:03 transgenic mice (negative control).