Local interactions captured additional genome-wide significant loci identified in GWAS of the eight traits in ARIC and/or NFBC1966.*

*: SNP1 (SNP2), pos1 (pos2) – name and position the first (second) SNP; Pint – P value of the interaction test; rep_SNP1 (rep_SNP2, rep_Pint) – the first (second, interaction P value) SNP of the best replicated pair; LD: r2 linkage disequilibrium between two epistatic SNPs.a: detected in NFBC1966 and test replication in ARIC;b: region shared in multiple traits;c: genome-wide significant marginal SNP.