The top 8 PPI targets in each of the three major groups: specific to nematodes (PPI-Nem), where both proteins contain indels with respect to human host (PPI-Indel2), with one indel with respect to human host (PPI-Indel1).

The full list is in Table S1.*indicates druggable, PPIs in bold italic were tested with FISH, and + indicates protein with indel, a RNAi phenotype 1 = Larval/Adult Lethal/Arrest, 2 = Embryonic Lethal, 3 = Sterility, 4 = Morphology, 5 = Growth, 6 = Movement, 7 = Vulva, 8 = Other; b Indicates analysis group (Nem, Indel2, and Indel1) and also the database where the PPI was found (M = MINT and I = IntAct), c Stages are listed as L1, L2, L3, L4, egg (Eg), embryo (Em), and Adult (A), d Localization in C. elegans listed as pharynx (P), intestine (I), reproductive (R), muscle (M), hypodermis (H), nervous system (N), somatic (S), embryo (E).